Write a short note on DNA replication?

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While proposing the double helical structure for DNA, Watson and Crick had immediately proposed a scheme for replication of DNA. The scheme suggested that the two strands would separate and act as a template for the synthesis of new complementary strands. After the completion of replication, each DNA molecule would have one parental and one newly synthesised strand.

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This scheme was termed as semiconservative DNA replication. In eukaryotes, the replication of DNA takes place at S-phase of the cell-cycle. The replication of DNA and cell division cycle should be highly coordinated

The major ingredients involved in DNA replication are as follows:
RNA Primer: Initiator of DNA synthesis
DNA Polymerase I: It removed the RNA Primer and replace with DNA. Further it polymerise the DNA fragment. It always work in 5’ to 3’ direction.
DNA ligase: to join the okazaki fragments.
Helicase: it unwind the double helical structure.

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